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Optimizing NTRK gene fusion detection

NTRK gene fusions are an important class of oncogenes which occur in a wide range of adult and pediatric tumor types.1 Several methods exist to detect genomic alterations. However, features unique to NTRK gene fusions must be considered during testing—making NTRK gene fusion detection an important challenge for pathologists.1,2

Optimizing testing for genomic alterations is the critical first step to identify NTRK gene fusions

This website provides information to help pathologists optimize their NTRK gene fusion testing process.

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Identifying Genomic Alterations
Identifying Genomic Alterations
Why Test for Genomic Alterations? Gene Fusions in Cancer
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NTRK Gene Fusions in Oncology
NTRK Gene Fusions in Oncology
What Are Gene Fusions? Role of NTRK Gene Fusions in Oncogenesis NTRK Gene Fusions in Cancer NTRK Gene Fusion Characteristics
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Detecting NTRK Gene Fusions
Detecting NTRK Gene Fusions
Key Methodologies Overview Guidelines for NTRK Gene Fusion Testing  NGS Testing IHC Testing FISH Testing RT-PCR Testing
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Optimizing NGS for NTRK  Gene Fusions
Optimizing NGS for NTRK  Gene Fusions
NGS Overview RNA- vs DNA-based NGS NGS Methodologies NGS Workflow Overview Preanalytic Phase Analytic Phase Postanalytic Phase Choosing a Commercial NGS Kit Reference NGS Laboratories
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Laboratory Considerations and Logistics
Laboratory Considerations and Logistics
Key Laboratory Considerations Tissue Sufficiency Across Tumors Sample Preparation Sample Considerations Across Methodologies Turnaround Across Methodologies Batching Considerations Across Methodologies
Resource Library

DNA, deoxyribonucleic acid; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; NGS, next-generation sequencing; NTRK, neurotrophic tyrosine receptor kinase; RNA, ribonucleic acid; RT-PCR, reverse-transcription polymerase chain reaction.

References: 1. Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1:e000023. 2. Vaishnavi A, Le AT, Doebele RC. Cancer Discov. 2015;5(1):25-34.